suppressMessages(require(knitr, quietly = T))
suppressMessages(require(kableExtra, quietly = T))
suppressMessages(require(rmarkdown, quietly = T))
suppressMessages(require(plyr, quietly = T))
suppressMessages(require(dplyr, quietly = T))
suppressMessages(require(ggplot2, quietly = T))
suppressMessages(require(GGally, quietly = T))
load("data.RData")
kable(df,
digits = 3,
row.names = T,
caption = "Raw data") %>%
kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive"),
font_size = 10) %>%
scroll_box(width = "100%", height = "300px")
| PatientID | Age | AgeGreater60 | Sex | LowIntermacs | InterMACS | RVAD | Sensitized | VAD Indication | Device Type | Survival | Outcome | Time | num Total PBMC | num lymph | lymph | live lymph | CD3 of live lymph | CD19 of live lymph | CD19+CD27- | CD19+CD27+ | CD27+38++plasma blasts | CD27-38++ transitional | CD27-IgD+ mature naive | CD27+IgD- switched memory | CD27-IgD- switched memory | CD27+IgD+ unswitched memory | CD27+IgD-IgM+ switched memory | CD27+IgD+IgM+ nonswitched memory | CD19+27+IgG+IgM- memory | CD19+24dim38dim naive mature | CD19+24+38++transitional | CD19CD24hiCD38-memory | CD19+27-38+CD5+transitionals | CD19+CD268+ | CD268 of +27-38++transitional | CD19+CD11b+ | CD19+CD5+ | CD19+CD27+CD24hi | CD19+CD5+CD24hi | CD19+CD5+CD11b+ | CD19+27+IgD-38++IgG ASC | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 15 | 70 | older | Female | High | 2 | No | NA | DT | HMII | alive | Alive | 0 | 86135 | 70306 | 81.62 | 93.71 | 74.50 | 1.59 | 61.74 | 38.26 | 1.91 | 2.67 | 33.97 | 14.50 | 26.81 | 24.71 | 20.67 | 62.47 | 9.03 | 73.00 | 2.00 | 24.71 | 1.27 | 20.23 | 71.43 | 0.48 | 12.79 | 0.38 | 3.24 | 0.48 | 4.60 |
| 2 | 15 | 70 | older | Female | High | 2 | No | NA | DT | HMII | alive | Alive | 1 | 81004 | 41334 | 51.03 | 94.06 | 53.64 | 2.99 | 61.70 | 38.30 | 3.10 | 2.75 | 39.07 | 13.34 | 22.12 | 25.47 | 12.58 | 63.11 | 15.99 | 78.92 | 2.93 | 17.38 | 3.35 | 23.24 | 71.88 | 0.52 | 11.70 | 0.09 | 1.29 | 0.52 | 9.83 |
| 3 | 15 | 70 | older | Female | High | 2 | No | NA | DT | HMII | alive | Alive | 3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 4 | 15 | 70 | older | Female | High | 2 | No | NA | DT | HMII | alive | Alive | 5 | 90024 | 39434 | 43.80 | 95.32 | 68.83 | 5.62 | 71.59 | 28.41 | 0.85 | 1.66 | 35.23 | 13.02 | 35.80 | 15.96 | 22.94 | 52.37 | 5.85 | 76.42 | 1.14 | 21.83 | 0.62 | 14.54 | 48.57 | 0.38 | 4.69 | 0.00 | 0.80 | 0.38 | 0.62 |
| 5 | 15 | 70 | older | Female | High | 2 | No | NA | DT | HMII | alive | Alive | 8 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 6 | 15 | 70 | older | Female | High | 2 | No | NA | DT | HMII | alive | Alive | 14 | 106791 | 80532 | 75.41 | 88.82 | 79.92 | 1.57 | 62.32 | 37.68 | 1.70 | 4.02 | 28.04 | 22.86 | 34.11 | 15.00 | 23.92 | 39.41 | 15.03 | 61.61 | 3.66 | 34.55 | 1.97 | 20.36 | 73.33 | 0.80 | 8.57 | 0.27 | 1.79 | 0.98 | 0.71 |
| 7 | 15 | 70 | older | Female | High | 2 | No | NA | DT | HMII | alive | Alive | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 8 | 22 | 67 | older | Male | High | 2 | Yes | NA | BTT | HMII | dead | Died | 0 | 129980 | 41600 | 32.00 | 91.40 | 39.03 | 2.85 | 49.63 | 50.37 | 7.02 | 11.55 | 28.37 | 29.11 | 20.79 | 21.72 | 19.43 | 28.34 | 9.80 | 69.59 | 4.90 | 20.33 | 6.13 | 31.15 | 33.60 | 20.15 | 22.27 | 0.28 | 4.25 | 16.54 | 2.09 |
| 9 | 22 | 67 | older | Male | High | 2 | Yes | NA | BTT | HMII | dead | Died | 1 | 59478 | 20182 | 33.93 | 89.07 | 44.50 | 10.08 | 60.93 | 39.07 | 2.10 | 2.70 | 42.88 | 13.69 | 17.66 | 25.77 | 13.06 | 46.12 | 3.13 | 81.35 | 1.16 | 16.11 | 0.83 | 37.58 | 6.12 | 5.52 | 11.64 | 0.06 | 1.49 | 2.76 | 4.07 |
| 10 | 22 | 67 | older | Male | High | 2 | Yes | NA | BTT | HMII | dead | Died | 3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 11 | 22 | 67 | older | Male | High | 2 | Yes | NA | BTT | HMII | dead | Died | 5 | 26646 | 9754 | 36.61 | 98.69 | 58.32 | 7.57 | 64.88 | 35.12 | 2.06 | 0.55 | 46.50 | 12.62 | 17.70 | 23.18 | 15.07 | 53.31 | 12.50 | 83.40 | 1.10 | 15.64 | 1.76 | 28.12 | 0.00 | 7.54 | 16.46 | 0.55 | 1.92 | 6.04 | 13.00 |
| 12 | 22 | 67 | older | Male | High | 2 | Yes | NA | BTT | HMII | dead | Died | 8 | 73641 | 21944 | 29.80 | 96.79 | 48.91 | 4.47 | 62.74 | 37.26 | 2.84 | 3.16 | 37.47 | 17.79 | 24.95 | 19.79 | 19.46 | 38.11 | 9.46 | 79.79 | 1.89 | 13.58 | 1.24 | 27.05 | 20.00 | 14.11 | 13.37 | 0.21 | 2.74 | 10.53 | 3.31 |
| 13 | 22 | 67 | older | Male | High | 2 | Yes | NA | BTT | HMII | dead | Died | 14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 14 | 22 | 67 | older | Male | High | 2 | Yes | NA | BTT | HMII | dead | Died | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 15 | 14 | 39 | younger | Female | Low | 3 | Yes | No | BTT | HMII | dead | Died post OHT | 0 | 52016 | 30920 | 59.44 | 95.77 | 55.57 | 24.62 | 58.73 | 41.27 | 2.14 | 0.97 | 53.01 | 5.05 | 5.45 | 36.50 | 9.39 | 81.29 | 2.88 | 81.48 | 5.65 | 9.02 | 0.48 | 97.75 | 71.83 | 0.67 | 22.89 | 0.34 | 1.78 | 0.49 | NA |
| 16 | 14 | 39 | younger | Female | Low | 3 | Yes | No | BTT | HMII | dead | Died post OHT | 1 | 75516 | 48801 | 64.62 | 92.13 | 52.90 | 18.64 | 70.39 | 29.61 | 2.92 | 2.21 | 62.18 | 5.13 | 7.98 | 24.70 | 13.79 | 69.54 | 3.19 | 84.14 | 3.64 | 6.36 | 0.41 | 94.93 | 43.78 | 0.57 | 15.61 | 0.23 | 0.91 | 0.36 | NA |
| 17 | 14 | 39 | younger | Female | Low | 3 | Yes | No | BTT | HMII | dead | Died post OHT | 3 | 250612 | 130454 | 52.05 | 95.75 | 60.05 | 3.29 | 46.04 | 53.96 | 1.34 | 3.89 | 33.08 | 32.47 | 8.29 | 26.15 | 3.56 | 34.61 | 0.09 | 76.71 | 0.39 | 13.20 | 0.28 | 39.79 | 14.38 | 2.26 | 1.56 | 10.45 | 2.89 | 3.04 | 0.08 |
| 18 | 14 | 39 | younger | Female | Low | 3 | Yes | No | BTT | HMII | dead | Died post OHT | 5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 19 | 14 | 39 | younger | Female | Low | 3 | Yes | No | BTT | HMII | dead | Died post OHT | 8 | 212478 | 120477 | 56.70 | 85.12 | 48.36 | 12.51 | 79.57 | 20.43 | 1.35 | 2.14 | 58.73 | 12.87 | 18.44 | 9.96 | 5.63 | 34.32 | 0.11 | 86.74 | 0.41 | 6.88 | 0.15 | 35.30 | 53.09 | 1.23 | 0.75 | 2.36 | 1.04 | 1.47 | NA |
| 20 | 14 | 39 | younger | Female | Low | 3 | Yes | No | BTT | HMII | dead | Died post OHT | 14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 21 | 14 | 39 | younger | Female | Low | 3 | Yes | No | BTT | HMII | dead | Died post OHT | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 22 | 3 | 58 | younger | Male | Low | 3 | Yes | No | BTT | HMII | alive | Alive s/p OHT | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 23 | 3 | 58 | younger | Male | Low | 3 | Yes | No | BTT | HMII | alive | Alive s/p OHT | 1 | 246811 | 86529 | 35.06 | 93.49 | 67.96 | 17.48 | 81.66 | 18.34 | 2.05 | 6.85 | 51.33 | 13.69 | 29.91 | 5.08 | 15.68 | 5.94 | 0.19 | 61.95 | 0.76 | 13.51 | 4.07 | 92.62 | 34.06 | 6.90 | 12.07 | 8.00 | 2.54 | 3.85 | 0.26 |
| 24 | 3 | 58 | younger | Male | Low | 3 | Yes | No | BTT | HMII | alive | Alive s/p OHT | 3 | 406771 | 90343 | 22.21 | 97.34 | 49.28 | 17.02 | 75.04 | 24.96 | 4.47 | 18.36 | 28.45 | 21.86 | 46.07 | 3.62 | 24.97 | 4.33 | 0.13 | 47.41 | 1.64 | 19.70 | 18.15 | 72.76 | 8.08 | 25.69 | 28.35 | 13.95 | 4.66 | 19.20 | 0.41 |
| 25 | 3 | 58 | younger | Male | Low | 3 | Yes | No | BTT | HMII | alive | Alive s/p OHT | 5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 26 | 3 | 58 | younger | Male | Low | 3 | Yes | No | BTT | HMII | alive | Alive s/p OHT | 8 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 27 | 3 | 58 | younger | Male | Low | 3 | Yes | No | BTT | HMII | alive | Alive s/p OHT | 14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 28 | 3 | 58 | younger | Male | Low | 3 | Yes | No | BTT | HMII | alive | Alive s/p OHT | 21 | 330191 | 81636 | 24.72 | 94.57 | 45.14 | 14.70 | 70.51 | 29.49 | 8.94 | 16.23 | 38.92 | 23.53 | 30.83 | 6.72 | 23.93 | 7.07 | 0.18 | 46.63 | 2.35 | 16.12 | 8.59 | 74.45 | 39.90 | 24.19 | 21.18 | 12.62 | 3.26 | 12.93 | 0.38 |
| 29 | 20 | 75 | older | Male | High | 2 | No | NA | DT | HMII | alive | Alive | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 30 | 20 | 75 | older | Male | High | 2 | No | NA | DT | HMII | alive | Alive | 1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 31 | 20 | 75 | older | Male | High | 2 | No | NA | DT | HMII | alive | Alive | 3 | 121794 | 28129 | 23.10 | 97.05 | 52.79 | 16.42 | 70.08 | 29.92 | 0.29 | 0.54 | 50.71 | 21.46 | 22.96 | 4.86 | 34.18 | 12.51 | 23.49 | 39.78 | 0.31 | 55.18 | 0.35 | 96.01 | 16.67 | 1.74 | 5.27 | 23.38 | 2.95 | 1.00 | 0.10 |
| 32 | 20 | 75 | older | Male | High | 2 | No | NA | DT | HMII | alive | Alive | 5 | 82157 | 17295 | 21.05 | 99.20 | 72.54 | 7.41 | 68.21 | 31.79 | 1.10 | 0.55 | 48.47 | 22.90 | 23.60 | 5.04 | 31.90 | 13.57 | 18.10 | 37.84 | 0.47 | 56.73 | 0.35 | 92.37 | 14.29 | 2.05 | 7.79 | 26.20 | 4.72 | 1.42 | 1.02 |
| 33 | 20 | 75 | older | Male | High | 2 | No | NA | DT | HMII | alive | Alive | 8 | 154810 | 27067 | 17.48 | 98.04 | 72.18 | 5.03 | 74.91 | 25.09 | 0.90 | 1.65 | 58.05 | 14.76 | 20.82 | 6.37 | 23.43 | 25.71 | 22.57 | 44.94 | 0.60 | 49.36 | 0.71 | 86.59 | 22.73 | 3.30 | 7.64 | 20.15 | 4.87 | 1.72 | 0.00 |
| 34 | 20 | 75 | older | Male | High | 2 | No | NA | DT | HMII | alive | Alive | 14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 35 | 20 | 75 | older | Male | High | 2 | No | NA | DT | HMII | alive | Alive | 21 | 197936 | 15446 | 7.80 | 95.86 | 50.35 | 5.44 | 79.13 | 20.87 | 3.98 | 3.11 | 52.30 | 15.90 | 29.81 | 1.99 | 20.23 | 5.78 | 24.86 | 40.62 | 1.12 | 50.06 | 1.89 | 62.36 | 8.00 | 7.20 | 9.94 | 13.17 | 3.60 | 5.09 | 1.55 |
| 36 | 24 | 64 | older | Male | High | 2 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 0 | 59881 | 8971 | 14.98 | 97.40 | 50.06 | 9.57 | 75.84 | 24.16 | 3.59 | 8.13 | 64.83 | 13.40 | 15.67 | 6.10 | 19.31 | 18.81 | 16.83 | 76.67 | 6.10 | 6.82 | 2.00 | 88.16 | 47.06 | 10.53 | 11.24 | 10.41 | 9.93 | 6.94 | 11.93 |
| 37 | 24 | 64 | older | Male | High | 2 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 1 | 60193 | 23874 | 39.66 | 96.72 | 58.83 | 16.24 | 80.37 | 19.63 | 1.87 | 3.31 | 68.58 | 10.62 | 14.72 | 6.08 | 21.33 | 22.83 | 3.80 | 80.61 | 3.63 | 8.03 | 0.33 | 94.16 | 57.26 | 2.96 | 5.01 | 10.19 | 4.72 | 1.41 | 1.24 |
| 38 | 24 | 64 | older | Male | High | 2 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 39 | 24 | 64 | older | Male | High | 2 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 5 | 135335 | 27834 | 20.57 | 97.35 | 44.75 | 5.61 | 63.22 | 36.78 | 8.49 | 17.63 | 39.01 | 23.16 | 30.72 | 7.11 | 17.53 | 10.38 | 12.16 | 42.70 | 4.93 | 19.28 | 4.68 | 67.37 | 4.10 | 26.64 | 17.76 | 19.21 | 14.54 | 14.47 | 10.60 |
| 40 | 24 | 64 | older | Male | High | 2 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 8 | 247113 | 62042 | 25.11 | 96.41 | 43.93 | 14.82 | 78.42 | 21.58 | 2.52 | 5.24 | 65.35 | 12.22 | 17.53 | 4.90 | 20.39 | 17.20 | 2.93 | 77.86 | 2.11 | 8.78 | 2.94 | 84.64 | 9.70 | 10.64 | 13.93 | 9.90 | 11.59 | 8.48 | 3.51 |
| 41 | 24 | 64 | older | Male | High | 2 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 14 | 142053 | 56983 | 40.11 | 93.01 | 62.72 | 12.87 | 85.10 | 14.90 | 0.69 | 1.64 | 68.02 | 8.40 | 21.03 | 2.55 | 17.03 | 13.68 | 1.08 | 83.33 | 0.37 | 7.38 | 0.26 | 79.00 | 16.07 | 3.01 | 5.85 | 5.16 | 5.24 | 1.77 | 0.70 |
| 42 | 24 | 64 | older | Male | High | 2 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 21 | 60384 | 17029 | 28.20 | 93.65 | 40.96 | 21.36 | 83.80 | 16.20 | 1.47 | 2.32 | 63.52 | 9.69 | 23.80 | 2.99 | 23.55 | 15.58 | 0.91 | 78.16 | 1.09 | 8.13 | 1.00 | 83.65 | 17.72 | 4.70 | 8.42 | 5.99 | 7.22 | 3.76 | 1.56 |
| 43 | 6 | 43 | younger | Male | High | 2 | Yes | No | BTT | HMII | alive | Alive s/p OHT | 0 | 515760 | 266115 | 51.60 | 96.30 | 69.66 | 8.57 | 72.22 | 27.78 | 6.26 | 4.77 | 43.09 | 26.01 | 28.26 | 2.63 | 16.67 | 2.67 | 28.25 | 50.35 | 0.41 | 12.78 | 4.47 | 84.76 | 19.47 | 9.56 | 4.55 | 8.29 | 0.87 | 2.18 | 0.75 |
| 44 | 6 | 43 | younger | Male | High | 2 | Yes | No | BTT | HMII | alive | Alive s/p OHT | 1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 45 | 6 | 43 | younger | Male | High | 2 | Yes | No | BTT | HMII | alive | Alive s/p OHT | 3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 46 | 6 | 43 | younger | Male | High | 2 | Yes | No | BTT | HMII | alive | Alive s/p OHT | 5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 47 | 6 | 43 | younger | Male | High | 2 | Yes | No | BTT | HMII | alive | Alive s/p OHT | 8 | 539521 | 223872 | 41.49 | 96.72 | 60.02 | 12.63 | 80.13 | 19.87 | 1.66 | 2.48 | 43.56 | 19.52 | 35.24 | 1.68 | 20.46 | 3.67 | 20.54 | 55.76 | 0.18 | 10.80 | 2.43 | 87.82 | 13.25 | 6.55 | 5.96 | 4.65 | 0.95 | 2.51 | 0.65 |
| 48 | 6 | 43 | younger | Male | High | 2 | Yes | No | BTT | HMII | alive | Alive s/p OHT | 14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 49 | 6 | 43 | younger | Male | High | 2 | Yes | No | BTT | HMII | alive | Alive s/p OHT | 21 | 564317 | 216312 | 38.33 | 97.40 | 55.80 | 4.83 | 74.19 | 25.81 | 5.35 | 5.77 | 37.90 | 25.72 | 34.76 | 1.62 | 17.99 | 2.18 | 31.75 | 61.61 | 0.77 | 13.44 | 6.97 | 76.55 | 6.97 | 10.34 | 11.14 | 4.46 | 0.94 | 5.14 | 2.43 |
| 50 | 5 | 65 | older | Female | High | 2 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 0 | 1073919 | 336538 | 31.34 | 100.00 | 63.29 | 14.80 | 93.05 | 6.95 | 0.73 | 8.05 | 75.49 | 4.55 | 19.16 | 0.80 | 7.25 | 8.78 | 28.04 | 88.72 | 2.51 | 5.18 | 1.02 | 90.49 | 68.18 | 2.32 | 4.09 | 1.69 | 3.48 | 1.27 | 5.78 |
| 51 | 5 | 65 | older | Female | High | 2 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 1 | 270301 | 97229 | 35.97 | 91.63 | 18.43 | 61.67 | 97.68 | 2.32 | 0.20 | 5.85 | 69.45 | 1.63 | 28.19 | 0.73 | 27.57 | 21.43 | 17.05 | 84.32 | 7.26 | 2.73 | 0.84 | 99.44 | 97.60 | 0.54 | 2.64 | 1.51 | 3.63 | 0.29 | 3.40 |
| 52 | 5 | 65 | older | Female | High | 2 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 3 | 499016 | 78019 | 15.63 | 89.41 | 25.83 | 51.38 | 92.98 | 7.02 | 0.32 | 4.66 | 51.34 | 6.31 | 41.59 | 0.76 | 36.49 | 5.96 | 22.81 | 73.48 | 6.73 | 7.93 | 0.33 | 98.78 | 96.52 | 1.31 | 2.06 | 5.19 | 2.68 | 0.59 | 2.45 |
| 53 | 5 | 65 | older | Female | High | 2 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 54 | 5 | 65 | older | Female | High | 2 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 8 | 115825 | 32513 | 28.07 | 91.04 | 44.61 | 15.76 | 80.52 | 19.48 | 4.16 | 7.82 | 49.91 | 18.37 | 30.52 | 1.20 | 14.87 | 3.33 | 30.19 | 61.08 | 8.70 | 12.56 | 1.58 | 89.80 | 76.71 | 2.87 | 6.07 | 11.12 | 8.08 | 1.59 | 1.17 |
| 55 | 5 | 65 | older | Female | High | 2 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 56 | 5 | 65 | older | Female | High | 2 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 21 | 407080 | 97651 | 23.99 | 91.29 | 66.96 | 12.20 | 84.66 | 15.34 | 2.88 | 5.60 | 61.89 | 13.73 | 22.65 | 1.74 | 20.16 | 7.23 | 29.39 | 68.49 | 5.28 | 10.60 | 1.17 | 92.50 | 54.35 | 3.48 | 6.53 | 9.61 | 8.34 | 1.85 | 2.83 |
| 57 | 23 | 68 | older | Male | High | 2 | No | No | BTT | HMII | alive | Alive s/p OHT | 0 | 44004 | 20612 | 46.84 | 43.65 | 15.61 | 21.54 | 49.64 | 50.36 | 10.37 | 0.57 | 15.94 | 45.15 | 33.18 | 5.73 | 24.69 | 5.68 | 20.25 | 44.58 | 1.55 | 36.17 | 0.88 | 67.23 | 27.27 | 32.35 | 15.48 | 20.02 | 4.49 | 10.94 | 2.76 |
| 58 | 23 | 68 | older | Male | High | 2 | No | No | BTT | HMII | alive | Alive s/p OHT | 1 | 99731 | 23424 | 23.49 | 91.81 | 41.33 | 10.89 | 35.24 | 64.76 | 11.83 | 1.62 | 18.71 | 59.21 | 16.19 | 5.89 | 28.16 | 5.89 | 18.53 | 39.98 | 4.66 | 42.16 | 2.33 | 84.07 | 2.63 | 22.55 | 15.21 | 40.28 | 6.07 | 9.70 | 3.96 |
| 59 | 23 | 68 | older | Male | High | 2 | No | No | BTT | HMII | alive | Alive s/p OHT | 3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 60 | 23 | 68 | older | Male | High | 2 | No | No | BTT | HMII | alive | Alive s/p OHT | 5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 61 | 23 | 68 | older | Male | High | 2 | No | No | BTT | HMII | alive | Alive s/p OHT | 8 | 129637 | 50001 | 38.57 | 90.65 | 44.41 | 6.05 | 30.66 | 69.34 | 17.12 | 4.05 | 10.62 | 66.50 | 19.60 | 3.28 | 26.41 | 3.46 | 13.37 | 39.74 | 7.15 | 39.49 | 11.91 | 71.97 | 2.70 | 32.48 | 33.14 | 43.91 | 7.81 | 22.70 | 3.82 |
| 62 | 23 | 68 | older | Male | High | 2 | No | No | BTT | HMII | alive | Alive s/p OHT | 14 | 134368 | 46363 | 34.50 | 88.32 | 34.25 | 4.63 | 32.47 | 67.53 | 12.86 | 8.38 | 8.91 | 64.89 | 22.88 | 3.32 | 24.78 | 3.89 | 13.58 | 36.16 | 6.01 | 40.33 | 13.77 | 72.11 | 1.89 | 29.89 | 26.36 | 42.80 | 6.17 | 15.97 | 3.29 |
| 63 | 23 | 68 | older | Male | High | 2 | No | No | BTT | HMII | alive | Alive s/p OHT | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 64 | 28 | 72 | older | Male | Low | 4 | Yes | NA | BTT | HMII | dead | Died | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 65 | 28 | 72 | older | Male | Low | 4 | Yes | NA | BTT | HMII | dead | Died | 1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 66 | 28 | 72 | older | Male | Low | 4 | Yes | NA | BTT | HMII | dead | Died | 3 | 424375 | 21971 | 5.18 | 71.78 | 56.98 | 18.53 | 79.84 | 20.16 | 3.08 | 0.51 | 57.91 | 14.07 | 24.06 | 3.97 | 31.74 | 15.95 | 13.65 | 57.94 | 0.65 | 28.51 | 0.17 | 93.57 | 53.33 | 2.87 | 9.69 | 15.61 | 3.87 | 2.16 | 3.99 |
| 67 | 28 | 72 | older | Male | Low | 4 | Yes | NA | BTT | HMII | dead | Died | 5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 68 | 28 | 72 | older | Male | Low | 4 | Yes | NA | BTT | HMII | dead | Died | 8 | 177249 | 103442 | 58.36 | 76.40 | 15.43 | 5.64 | 65.13 | 34.87 | 5.21 | 0.20 | 35.56 | 27.91 | 31.90 | 4.62 | 26.60 | 8.28 | 13.24 | 67.89 | 0.29 | 20.13 | 0.00 | 78.60 | 22.22 | 5.50 | 16.09 | 25.56 | 6.80 | 4.73 | 0.89 |
| 69 | 28 | 72 | older | Male | Low | 4 | Yes | NA | BTT | HMII | dead | Died | 14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 70 | 28 | 72 | older | Male | Low | 4 | Yes | NA | BTT | HMII | dead | Died | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 71 | 18 | 37 | younger | Female | High | 2 | Yes | NA | BTT | PVAD | dead | Died s/p OHT | 0 | 56374 | 12141 | 21.54 | 67.38 | 27.12 | 3.32 | 51.84 | 48.16 | 1.84 | 1.84 | 2.94 | 45.59 | 47.79 | 3.68 | 0.00 | 0.00 | 2.29 | 92.65 | 0.37 | 5.51 | 0.72 | 30.15 | 60.00 | 6.99 | 9.56 | 0.37 | 0.00 | 3.68 | 0.00 |
| 72 | 18 | 37 | younger | Female | High | 2 | Yes | NA | BTT | PVAD | dead | Died s/p OHT | 1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 73 | 18 | 37 | younger | Female | High | 2 | Yes | NA | BTT | PVAD | dead | Died s/p OHT | 3 | 7018 | 3464 | 49.36 | 89.03 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| 74 | 18 | 37 | younger | Female | High | 2 | Yes | NA | BTT | PVAD | dead | Died s/p OHT | 5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 75 | 18 | 37 | younger | Female | High | 2 | Yes | NA | BTT | PVAD | dead | Died s/p OHT | 8 | 80210 | 21828 | 27.21 | 85.74 | 20.38 | 3.50 | 61.98 | 38.02 | 8.55 | 2.90 | 5.50 | 34.96 | 56.18 | 3.36 | 0.00 | 0.00 | 3.21 | 89.31 | 0.61 | 2.60 | 1.49 | 23.66 | 0.00 | 21.37 | 9.16 | 1.07 | 0.15 | 5.34 | 1.31 |
| 76 | 18 | 37 | younger | Female | High | 2 | Yes | NA | BTT | PVAD | dead | Died s/p OHT | 14 | 55068 | 19145 | 34.77 | 75.16 | 16.90 | 3.30 | 64.00 | 36.00 | 4.21 | 2.11 | 10.53 | 34.11 | 52.42 | 2.95 | 0.00 | 0.00 | 2.94 | 92.42 | 0.00 | 3.37 | 1.00 | 22.74 | 0.00 | 12.42 | 11.16 | 0.63 | 0.00 | 4.63 | 0.00 |
| 77 | 18 | 37 | younger | Female | High | 2 | Yes | NA | BTT | PVAD | dead | Died s/p OHT | 21 | 76673 | 23615 | 30.80 | 83.39 | 26.27 | 2.06 | 63.55 | 36.45 | 5.42 | 5.42 | 5.17 | 34.48 | 58.13 | 2.22 | 0.00 | 0.00 | 2.72 | 89.41 | 0.00 | 3.45 | 1.95 | 18.23 | 4.55 | 18.23 | 8.87 | 1.23 | 0.25 | 4.68 | 0.00 |
| 78 | 10 | 36 | younger | Male | High | 2 | Yes | NA | BTT | PVAD | alive | Alive s/p OHT | 0 | 481928 | 162052 | 33.63 | 99.70 | 64.73 | 5.05 | 3.91 | 96.09 | 8.89 | 1.34 | 0.72 | 94.99 | 3.14 | 1.15 | 4.07 | 0.84 | 0.32 | 90.28 | 2.84 | 1.58 | 1.27 | 6.82 | 9.17 | 14.61 | 90.11 | 4.95 | 5.71 | 13.01 | 0.51 |
| 79 | 10 | 36 | younger | Male | High | 2 | Yes | NA | BTT | PVAD | alive | Alive s/p OHT | 1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 80 | 10 | 36 | younger | Male | High | 2 | Yes | NA | BTT | PVAD | alive | Alive s/p OHT | 3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 81 | 10 | 36 | younger | Male | High | 2 | Yes | NA | BTT | PVAD | alive | Alive s/p OHT | 5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 82 | 10 | 36 | younger | Male | High | 2 | Yes | NA | BTT | PVAD | alive | Alive s/p OHT | 8 | 38113 | 21486 | 56.37 | 97.86 | 58.44 | 7.88 | 20.47 | 79.53 | 8.09 | 1.69 | 1.21 | 75.00 | 18.96 | 4.83 | 10.07 | 2.59 | 0.53 | 82.19 | 2.29 | 9.00 | 3.59 | 15.16 | 0.00 | 23.07 | 63.95 | 4.77 | 6.52 | 16.91 | 0.40 |
| 83 | 10 | 36 | younger | Male | High | 2 | Yes | NA | BTT | PVAD | alive | Alive s/p OHT | 14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 84 | 10 | 36 | younger | Male | High | 2 | Yes | NA | BTT | PVAD | alive | Alive s/p OHT | 21 | 80991 | 19210 | 23.72 | 99.00 | 50.61 | 3.50 | 12.33 | 87.67 | 14.74 | 4.81 | 1.05 | 85.41 | 11.13 | 2.41 | 8.48 | 0.52 | 1.56 | 80.00 | 8.27 | 3.76 | 7.41 | 13.68 | 0.00 | 30.83 | 77.74 | 10.83 | 14.14 | 19.85 | 2.81 |
| 85 | 21 | 30 | younger | Female | Low | 3 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 0 | 114586 | 35996 | 31.41 | 100.00 | 59.03 | 11.31 | 75.87 | 24.13 | 1.52 | 7.69 | 69.83 | 11.67 | 10.20 | 8.30 | 27.80 | 29.94 | 2.04 | 84.64 | 0.64 | 10.54 | 0.61 | 91.57 | 61.34 | 4.99 | 7.15 | 11.57 | 5.92 | 2.53 | 1.92 |
| 86 | 21 | 30 | younger | Female | Low | 3 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 87 | 21 | 30 | younger | Female | Low | 3 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 3 | 349054 | 129419 | 37.08 | 95.25 | 62.35 | 8.81 | 79.64 | 20.36 | 2.72 | 4.45 | 57.70 | 13.93 | 25.89 | 2.48 | 57.14 | 13.49 | 8.69 | 74.29 | 3.76 | 12.35 | 1.41 | 85.87 | 62.53 | 3.41 | 5.43 | 7.67 | 1.40 | 1.92 | 1.06 |
| 88 | 21 | 30 | younger | Female | Low | 3 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 5 | 447309 | 176789 | 39.52 | 93.00 | 53.57 | 9.32 | 80.92 | 19.08 | 2.16 | 5.73 | 56.72 | 12.51 | 28.43 | 2.34 | 47.68 | 12.19 | 11.00 | 73.80 | 4.44 | 12.53 | 2.57 | 83.88 | 49.09 | 5.24 | 6.82 | 8.32 | 2.18 | 2.28 | 1.72 |
| 89 | 21 | 30 | younger | Female | Low | 3 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 8 | 558290 | 301468 | 54.00 | 95.62 | 47.73 | 7.04 | 79.13 | 20.87 | 3.43 | 7.49 | 53.19 | 13.48 | 30.32 | 3.01 | 36.36 | 14.54 | 12.10 | 70.55 | 5.15 | 11.89 | 3.51 | 79.79 | 52.89 | 6.98 | 8.50 | 7.82 | 1.92 | 3.09 | 1.96 |
| 90 | 21 | 30 | younger | Female | Low | 3 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 14 | 479402 | 362845 | 75.69 | 97.95 | 44.30 | 6.30 | 76.53 | 23.47 | 3.90 | 11.10 | 34.99 | 12.04 | 50.31 | 2.66 | 21.93 | 14.88 | 10.05 | 70.21 | 4.66 | 7.31 | 7.73 | 49.96 | 29.38 | 13.44 | 17.37 | 5.64 | 3.01 | 6.95 | 2.28 |
| 91 | 21 | 30 | younger | Female | Low | 3 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 21 | 334942 | 191418 | 57.15 | 93.28 | 70.35 | 4.04 | 70.89 | 29.11 | 6.20 | 17.70 | 56.45 | 19.57 | 20.44 | 3.53 | 38.91 | 14.64 | 10.35 | 55.11 | 6.61 | 14.34 | 8.70 | 80.96 | 58.92 | 7.58 | 7.96 | 10.11 | 2.08 | 2.08 | 2.48 |
| 92 | 8 | 43 | younger | Male | Low | 3 | No | No | BTT | HMII | alive | Alive s/p OHT | 0 | 92221 | 27988 | 30.35 | 85.45 | 55.78 | 1.51 | 85.56 | 14.44 | 0.28 | 0.28 | 55.28 | 4.72 | 39.72 | 0.28 | 0.00 | 1.89 | 1.89 | 89.44 | 0.00 | 2.78 | 0.00 | 15.00 | 0.00 | 3.33 | 0.83 | 0.28 | 0.28 | 3.33 | 0.00 |
| 93 | 8 | 43 | younger | Male | Low | 3 | No | No | BTT | HMII | alive | Alive s/p OHT | 1 | 273746 | 46755 | 17.08 | 93.25 | 50.14 | 7.57 | 88.27 | 11.73 | 0.09 | 2.12 | 54.52 | 3.36 | 42.00 | 0.12 | 8.40 | 6.87 | 0.00 | 92.00 | 0.12 | 3.45 | 0.00 | 3.94 | 11.43 | 1.12 | 0.64 | 2.76 | 0.33 | 2.15 | 0.00 |
| 94 | 8 | 43 | younger | Male | Low | 3 | No | No | BTT | HMII | alive | Alive s/p OHT | 3 | 156053 | 71752 | 45.98 | 78.38 | 35.43 | 27.12 | 78.57 | 21.43 | 0.24 | 0.60 | 58.56 | 5.80 | 18.33 | 17.31 | 12.67 | 72.96 | 0.53 | 94.06 | 0.49 | 5.11 | 0.28 | 22.79 | 27.47 | 0.81 | 5.53 | 0.01 | 0.29 | 0.19 | 0.00 |
| 95 | 8 | 43 | younger | Male | Low | 3 | No | No | BTT | HMII | alive | Alive s/p OHT | 5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 96 | 8 | 43 | younger | Male | Low | 3 | No | No | BTT | HMII | alive | Alive s/p OHT | 8 | 156053 | 71752 | 45.98 | 78.38 | 35.43 | 27.12 | 78.57 | 21.43 | 0.24 | 0.60 | 58.56 | 5.80 | 18.33 | 17.31 | 12.67 | 72.96 | 0.53 | 94.06 | 0.49 | 5.11 | 0.28 | 22.79 | 27.47 | 0.81 | 5.53 | 0.01 | 0.29 | 0.19 | 0.00 |
| 97 | 8 | 43 | younger | Male | Low | 3 | No | No | BTT | HMII | alive | Alive s/p OHT | 14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 98 | 8 | 43 | younger | Male | Low | 3 | No | No | BTT | HMII | alive | Alive s/p OHT | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 99 | 16 | 63 | older | Male | High | 1 | No | NA | BTT | HMII | dead | Died | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 100 | 16 | 63 | older | Male | High | 1 | No | NA | BTT | HMII | dead | Died | 1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 101 | 16 | 63 | older | Male | High | 1 | No | NA | BTT | HMII | dead | Died | 3 | 366713 | 77282 | 21.07 | 98.61 | 66.55 | 12.44 | 93.65 | 6.35 | 0.53 | 0.60 | 62.22 | 4.68 | 32.38 | 0.72 | 19.94 | 9.89 | 28.23 | 83.18 | 0.51 | 14.38 | 0.30 | 94.72 | 54.39 | 2.07 | 11.33 | 2.86 | 3.40 | 1.48 | 3.58 |
| 102 | 16 | 63 | older | Male | High | 1 | No | NA | BTT | HMII | dead | Died | 5 | 262251 | 55344 | 21.10 | 99.55 | 62.37 | 14.39 | 93.00 | 7.00 | 1.03 | 0.69 | 65.71 | 4.74 | 28.37 | 1.17 | 25.93 | 17.28 | 25.93 | 79.87 | 1.20 | 17.05 | 0.48 | 97.76 | 58.18 | 2.27 | 11.13 | 4.12 | 4.91 | 1.87 | 6.10 |
| 103 | 16 | 63 | older | Male | High | 1 | No | NA | BTT | HMII | dead | Died | 8 | 309193 | 61091 | 19.76 | 98.15 | 56.62 | 7.24 | 83.61 | 16.39 | 3.27 | 1.52 | 58.03 | 11.90 | 28.13 | 1.93 | 24.65 | 11.36 | 1.52 | 79.53 | 1.45 | 13.33 | 0.97 | 92.63 | 25.76 | 3.50 | 9.23 | 7.57 | 3.73 | 3.48 | 0.00 |
| 104 | 16 | 63 | older | Male | High | 1 | No | NA | BTT | HMII | dead | Died | 14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 105 | 16 | 63 | older | Male | High | 1 | No | NA | BTT | HMII | dead | Died | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 106 | 11 | 61 | older | Male | High | 2 | No | No | BTT | HMII | alive | Alive s/p OHT | 0 | 411616 | 119210 | 28.96 | 90.82 | 73.63 | 5.88 | 74.30 | 25.70 | 2.80 | 6.46 | 57.94 | 19.20 | 18.72 | 4.13 | 19.10 | 15.42 | 15.30 | 53.51 | 13.78 | 25.19 | 0.21 | 47.23 | 53.77 | 5.75 | 5.92 | 22.63 | 3.46 | 2.55 | 0.74 |
| 107 | 11 | 61 | older | Male | High | 2 | No | No | BTT | HMII | alive | Alive s/p OHT | 1 | 430509 | 79492 | 18.46 | 89.31 | 52.10 | 20.45 | 87.13 | 12.87 | 1.23 | 4.76 | 58.11 | 9.15 | 30.55 | 2.20 | 29.86 | 18.05 | 10.37 | 63.63 | 10.23 | 17.43 | 0.06 | 74.05 | 72.50 | 2.36 | 2.98 | 10.68 | 1.72 | 1.03 | 2.89 |
| 108 | 11 | 61 | older | Male | High | 2 | No | No | BTT | HMII | alive | Alive s/p OHT | 3 | 395713 | 119670 | 30.24 | 97.90 | 23.79 | 6.27 | 82.17 | 17.83 | 0.79 | 1.99 | 49.95 | 13.01 | 33.91 | 3.13 | 28.36 | 16.83 | 5.00 | 56.33 | 7.13 | 26.73 | 0.02 | 79.50 | 82.88 | 1.96 | 5.55 | 16.30 | 3.61 | 1.88 | 0.42 |
| 109 | 11 | 61 | older | Male | High | 2 | No | No | BTT | HMII | alive | Alive s/p OHT | 5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 110 | 11 | 61 | older | Male | High | 2 | No | No | BTT | HMII | alive | Alive s/p OHT | 8 | 329840 | 73468 | 22.27 | 98.63 | 70.61 | 3.73 | 51.50 | 48.50 | 8.32 | 3.77 | 33.46 | 41.29 | 20.92 | 4.33 | 25.19 | 5.89 | 24.07 | 46.40 | 3.73 | 34.64 | 0.07 | 64.14 | 28.43 | 10.35 | 9.61 | 38.78 | 4.62 | 5.55 | 2.91 |
| 111 | 11 | 61 | older | Male | High | 2 | No | No | BTT | HMII | alive | Alive s/p OHT | 14 | 350294 | 88823 | 25.36 | 97.63 | 74.37 | 4.37 | 73.35 | 26.65 | 4.91 | 4.83 | 56.54 | 21.32 | 19.84 | 2.30 | 34.68 | 11.25 | 18.37 | 61.98 | 5.78 | 20.55 | 0.04 | 63.91 | 47.54 | 6.81 | 6.17 | 21.77 | 2.90 | 2.74 | 3.00 |
| 112 | 11 | 61 | older | Male | High | 2 | No | No | BTT | HMII | alive | Alive s/p OHT | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 113 | 4 | 67 | older | Male | Low | 3 | No | Yes | BTT | HVAD | alive | Alive s/p OHT | 0 | 309890 | 41896 | 13.52 | 97.03 | 47.13 | 8.08 | 77.31 | 22.69 | 2.74 | 3.29 | 59.03 | 19.80 | 19.37 | 1.80 | 21.10 | 4.46 | 19.79 | 71.98 | 2.41 | 17.39 | 0.20 | 95.80 | 75.00 | 5.79 | 1.89 | 16.45 | 0.91 | 0.67 | 0.77 |
| 114 | 4 | 67 | older | Male | Low | 3 | No | Yes | BTT | HVAD | alive | Alive s/p OHT | 1 | 274228 | 15653 | 5.71 | 97.85 | 35.76 | 28.87 | 51.45 | 48.55 | 2.60 | 2.13 | 30.85 | 43.13 | 22.77 | 3.26 | 20.09 | 3.92 | 30.51 | 57.58 | 1.31 | 28.20 | 0.18 | 91.23 | 59.57 | 12.08 | 2.04 | 34.44 | 0.38 | 0.16 | 0.16 |
| 115 | 4 | 67 | older | Male | Low | 3 | No | Yes | BTT | HVAD | alive | Alive s/p OHT | 3 | 591939 | 57589 | 9.73 | 96.76 | 38.20 | 42.54 | 75.71 | 24.29 | 2.14 | 1.33 | 53.03 | 21.26 | 24.16 | 1.55 | 25.50 | 4.02 | 20.27 | 67.18 | 1.14 | 21.71 | 0.11 | 95.28 | 66.98 | 3.79 | 2.43 | 17.70 | 0.65 | 0.84 | 0.18 |
| 116 | 4 | 67 | older | Male | Low | 3 | No | Yes | BTT | HVAD | alive | Alive s/p OHT | 5 | 189634 | 46711 | 24.63 | 97.74 | 34.84 | 37.32 | 75.30 | 24.70 | 0.70 | 0.55 | 46.97 | 22.05 | 30.28 | 0.70 | 23.67 | 1.56 | 31.44 | 73.33 | 0.75 | 18.59 | 0.00 | 84.61 | 86.17 | 3.44 | 2.11 | 18.68 | 0.94 | 0.63 | 0.69 |
| 117 | 4 | 67 | older | Male | Low | 3 | No | Yes | BTT | HVAD | alive | Alive s/p OHT | 8 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 118 | 4 | 67 | older | Male | Low | 3 | No | Yes | BTT | HVAD | alive | Alive s/p OHT | 14 | 182319 | 40475 | 22.20 | 96.28 | 43.36 | 11.77 | 69.34 | 30.66 | 1.59 | 0.89 | 52.64 | 27.32 | 18.56 | 1.48 | 22.79 | 2.88 | 28.61 | 75.47 | 0.33 | 14.54 | 0.06 | 95.90 | 53.66 | 7.81 | 3.27 | 21.04 | 1.57 | 1.50 | 0.72 |
| 119 | 4 | 67 | older | Male | Low | 3 | No | Yes | BTT | HVAD | alive | Alive s/p OHT | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 120 | 25 | 25 | younger | Female | Low | 3 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 0 | 47645 | 37377 | 78.45 | 94.61 | 2.47 | 9.41 | 78.56 | 17.02 | 1.71 | 4.63 | 34.94 | 16.09 | 44.77 | 4.21 | 4.35 | 28.99 | 59.42 | 67.26 | 3.10 | 26.22 | 7.50 | 72.82 | 53.90 | 13.50 | 28.20 | 3.04 | 7.70 | 7.67 | 0.96 |
| 121 | 25 | 25 | younger | Female | Low | 3 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 1 | 87452 | 43025 | 49.20 | 91.54 | 1.98 | 26.71 | 92.06 | 6.76 | 0.77 | 4.67 | 47.21 | 4.70 | 45.17 | 2.92 | 6.06 | 18.18 | 60.61 | 81.01 | 3.95 | 14.10 | 12.04 | 85.97 | 79.84 | 5.82 | 14.15 | 1.11 | 4.77 | 2.84 | 0.00 |
| 122 | 25 | 25 | younger | Female | Low | 3 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 3 | 124056 | 80873 | 65.19 | 95.41 | 0.37 | 14.36 | 90.47 | 5.98 | 0.39 | 0.60 | 41.84 | 4.26 | 51.08 | 2.81 | 18.82 | 35.29 | 43.53 | 86.97 | 0.10 | 11.32 | 1.10 | 75.49 | 12.12 | 3.80 | 14.94 | 0.24 | 0.88 | 3.25 | 0.00 |
| 123 | 25 | 25 | younger | Female | Low | 3 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 124 | 25 | 25 | younger | Female | Low | 3 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 8 | 87840 | 57990 | 66.02 | 95.60 | 0.11 | 15.80 | 89.00 | 9.49 | 1.56 | 5.02 | 45.89 | 7.18 | 43.54 | 3.39 | 6.10 | 19.51 | 56.71 | 84.23 | 3.14 | 9.95 | 10.70 | 72.13 | 52.73 | 7.06 | 17.53 | 0.74 | 3.13 | 5.13 | 0.13 |
| 125 | 25 | 25 | younger | Female | Low | 3 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 126 | 25 | 25 | younger | Female | Low | 3 | No | Yes | BTT | HMII | alive | Alive s/p OHT | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 127 | 27 | 62 | older | Male | High | 2 | No | NA | BTT | CMAG | dead | Died | 0 | 105070 | 38521 | 36.66 | 98.39 | 47.84 | 12.88 | 60.82 | 39.18 | 11.08 | 2.89 | 33.87 | 29.43 | 26.68 | 10.01 | 19.72 | 21.92 | 2.99 | 59.35 | 14.64 | 20.23 | 3.45 | 81.40 | 46.10 | 24.47 | 24.27 | 24.04 | 11.00 | 17.02 | 1.51 |
| 128 | 27 | 62 | older | Male | High | 2 | No | NA | BTT | CMAG | dead | Died | 1 | 162336 | 73080 | 45.02 | 99.08 | 49.35 | 13.95 | 74.24 | 25.76 | 7.77 | 3.84 | 45.21 | 19.33 | 28.85 | 6.61 | 19.16 | 23.45 | 0.81 | 65.34 | 14.40 | 13.50 | 3.17 | 86.68 | 71.39 | 23.26 | 17.70 | 15.21 | 6.93 | 13.29 | 0.88 |
| 129 | 27 | 62 | older | Male | High | 2 | No | NA | BTT | CMAG | dead | Died | 3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 130 | 27 | 62 | older | Male | High | 2 | No | NA | BTT | CMAG | dead | Died | 5 | 111264 | 60487 | 54.36 | 99.15 | 45.94 | 16.13 | 73.16 | 26.84 | 4.64 | 1.82 | 52.04 | 20.07 | 20.94 | 6.95 | 22.93 | 23.47 | 0.50 | 77.11 | 9.30 | 9.58 | 1.20 | 88.92 | 81.82 | 22.20 | 19.01 | 16.98 | 6.89 | 13.57 | 1.36 |
| 131 | 27 | 62 | older | Male | High | 2 | No | NA | BTT | CMAG | dead | Died | 8 | 165870 | 67935 | 40.96 | 98.88 | 43.01 | 15.86 | 70.23 | 29.77 | 7.85 | 1.88 | 40.39 | 20.49 | 29.66 | 9.46 | 22.70 | 29.00 | 1.88 | 68.61 | 9.60 | 16.11 | 1.47 | 89.57 | 69.00 | 20.12 | 16.59 | 17.10 | 7.02 | 12.40 | 2.06 |
| 132 | 27 | 62 | older | Male | High | 2 | No | NA | BTT | CMAG | dead | Died | 14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 133 | 27 | 62 | older | Male | High | 2 | No | NA | BTT | CMAG | dead | Died | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 134 | 13 | 61 | older | Male | High | 1 | Yes | No | BTT | TAH | alive | Alive s/p OHT | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 135 | 13 | 61 | older | Male | High | 1 | Yes | No | BTT | TAH | alive | Alive s/p OHT | 1 | 87827 | 15751 | 17.93 | 76.38 | 31.60 | 12.17 | 77.46 | 22.54 | 6.35 | 2.53 | 50.34 | 20.22 | 27.05 | 2.39 | 19.68 | 7.62 | 19.05 | 75.55 | 7.38 | 9.49 | 0.71 | 94.26 | 89.19 | 11.68 | 17.96 | 18.78 | 6.97 | 10.86 | 12.46 |
| 136 | 13 | 61 | older | Male | High | 1 | Yes | No | BTT | TAH | alive | Alive s/p OHT | 3 | 55539 | 13608 | 24.50 | 79.00 | 28.02 | 15.78 | 81.90 | 18.10 | 6.13 | 2.42 | 66.92 | 14.33 | 14.98 | 3.77 | 20.81 | 17.45 | 18.12 | 78.01 | 7.08 | 8.61 | 0.72 | 94.04 | 70.73 | 11.32 | 16.69 | 15.21 | 5.78 | 10.50 | 16.39 |
| 137 | 13 | 61 | older | Male | High | 1 | Yes | No | BTT | TAH | alive | Alive s/p OHT | 5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 138 | 13 | 61 | older | Male | High | 1 | Yes | No | BTT | TAH | alive | Alive s/p OHT | 8 | 295005 | 36785 | 12.47 | 94.58 | 36.55 | 9.14 | 86.32 | 13.68 | 2.45 | 1.82 | 37.01 | 12.52 | 49.18 | 1.29 | 16.24 | 4.71 | 12.47 | 8.36 | 1.73 | 6.64 | 0.81 | 84.78 | 46.55 | 12.52 | 9.28 | 5.94 | 1.73 | 4.47 | 2.49 |
| 139 | 13 | 61 | older | Male | High | 1 | Yes | No | BTT | TAH | alive | Alive s/p OHT | 14 | 60695 | 20471 | 33.73 | 94.91 | 6.93 | 7.42 | 83.97 | 16.03 | 3.40 | 0.69 | 24.36 | 14.71 | 59.33 | 1.60 | 18.43 | 5.07 | 11.52 | 54.82 | 2.91 | 16.10 | 0.50 | 82.44 | 30.00 | 51.08 | 13.25 | 10.41 | 3.68 | 11.31 | 6.06 |
| 140 | 13 | 61 | older | Male | High | 1 | Yes | No | BTT | TAH | alive | Alive s/p OHT | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 141 | 19 | 46 | younger | Male | High | 2 | No | NA | DT | HMII | alive | Alive | 0 | 226762 | 25868 | 11.41 | 89.41 | 25.31 | 12.05 | 55.06 | 44.94 | 11.31 | 2.69 | 14.79 | 42.57 | 39.95 | 2.69 | 19.87 | 3.88 | 32.88 | 68.95 | 10.48 | 13.57 | 0.59 | 80.62 | 22.67 | 31.91 | 19.38 | 15.58 | 10.37 | 16.55 | 8.18 |
| 142 | 19 | 46 | younger | Male | High | 2 | No | NA | DT | HMII | alive | Alive | 1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 143 | 19 | 46 | younger | Male | High | 2 | No | NA | DT | HMII | alive | Alive | 3 | 244049 | 39386 | 16.14 | 94.94 | 40.46 | 13.23 | 40.93 | 59.07 | 13.36 | 3.17 | 8.33 | 54.90 | 32.28 | 4.49 | 18.52 | 4.21 | 23.83 | 55.18 | 13.87 | 19.39 | 1.44 | 70.53 | 35.67 | 33.62 | 33.47 | 22.86 | 15.26 | 25.81 | 5.11 |
| 144 | 19 | 46 | younger | Male | High | 2 | No | NA | DT | HMII | alive | Alive | 5 | 344736 | 250121 | 72.55 | 89.83 | 7.54 | 3.81 | 45.84 | 54.16 | 3.96 | 1.53 | 13.39 | 52.70 | 32.18 | 1.72 | 67.14 | 2.92 | 2.44 | 74.68 | 6.81 | 13.91 | 0.21 | 63.33 | 58.02 | 33.05 | 30.94 | 19.83 | 13.96 | 26.74 | 0.22 |
| 145 | 19 | 46 | younger | Male | High | 2 | No | NA | DT | HMII | alive | Alive | 8 | 216934 | 140093 | 64.58 | 96.37 | 4.78 | 7.22 | 22.49 | 77.51 | 13.49 | 0.64 | 7.22 | 67.61 | 15.17 | 10.00 | 35.88 | 7.82 | 17.22 | 51.28 | 39.40 | 6.56 | 1.33 | 62.59 | 58.06 | 66.67 | 64.59 | 53.00 | 50.26 | 63.78 | 4.97 |
| 146 | 19 | 46 | younger | Male | High | 2 | No | NA | DT | HMII | alive | Alive | 14 | 215820 | 66785 | 30.94 | 92.54 | 17.20 | 6.01 | 25.88 | 74.12 | 9.15 | 1.45 | 3.09 | 71.72 | 22.44 | 2.74 | 65.43 | 3.42 | 0.04 | 69.38 | 15.93 | 8.85 | 0.74 | 50.58 | 24.07 | 52.78 | 48.88 | 32.28 | 28.19 | 44.04 | 0.04 |
| 147 | 19 | 46 | younger | Male | High | 2 | No | NA | DT | HMII | alive | Alive | 21 | 670692 | 523014 | 77.98 | 96.05 | 5.07 | 2.64 | 23.61 | 76.39 | 4.11 | 0.49 | 4.79 | 73.53 | 18.68 | 3.00 | 42.40 | 2.72 | 4.49 | 71.95 | 20.81 | 5.51 | 0.45 | 48.22 | 44.62 | 60.13 | 60.26 | 39.07 | 36.82 | 56.38 | 1.49 |
| 148 | 2 | 81 | older | Male | Low | 3 | No | NA | DT | HMII | dead | Died | 0 | 119377 | 77509 | 64.93 | 99.61 | 58.50 | 7.99 | 62.67 | 37.33 | 9.10 | 4.82 | 36.73 | 31.90 | 25.62 | 5.74 | 11.47 | 8.95 | 0.40 | 69.54 | 7.69 | 9.41 | 2.61 | 76.44 | 57.91 | 23.29 | 20.76 | 15.39 | 5.42 | 14.90 | 2.60 |
| 149 | 2 | 81 | older | Male | Low | 3 | No | NA | DT | HMII | dead | Died | 1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 150 | 2 | 81 | older | Male | Low | 3 | No | NA | DT | HMII | dead | Died | 3 | 96940 | 57658 | 59.48 | 99.70 | 55.52 | 9.21 | 72.15 | 27.85 | 3.85 | 3.82 | 48.41 | 21.75 | 23.49 | 6.35 | 12.10 | 16.04 | 0.28 | 75.30 | 3.72 | 6.65 | 2.11 | 80.52 | 67.33 | 15.80 | 15.23 | 6.71 | 1.32 | 8.86 | 0.26 |
| 151 | 2 | 81 | older | Male | Low | 3 | No | NA | DT | HMII | dead | Died | 5 | 154373 | 73969 | 47.92 | 99.65 | 45.18 | 8.77 | 67.36 | 32.64 | 6.59 | 2.77 | 39.10 | 26.28 | 27.95 | 6.67 | 17.89 | 15.71 | 0.39 | 71.57 | 6.26 | 9.88 | 1.78 | 81.86 | 72.07 | 20.12 | 20.17 | 14.80 | 5.99 | 14.65 | 3.71 |
| 152 | 2 | 81 | older | Male | Low | 3 | No | NA | DT | HMII | dead | Died | 8 | 155610 | 63375 | 40.73 | 99.51 | 38.42 | 12.40 | 71.69 | 28.31 | 4.36 | 2.62 | 37.82 | 23.43 | 33.50 | 5.24 | 17.37 | 14.92 | 0.60 | 65.04 | 2.80 | 11.23 | 2.54 | 83.55 | 37.56 | 15.55 | 15.45 | 9.55 | 2.66 | 10.91 | 0.28 |
| 153 | 2 | 81 | older | Male | Low | 3 | No | NA | DT | HMII | dead | Died | 14 | 244245 | 115109 | 47.13 | 99.47 | 47.40 | 9.37 | 67.50 | 32.50 | 3.99 | 2.08 | 50.08 | 26.01 | 17.22 | 6.68 | 15.34 | 15.25 | 0.23 | 77.86 | 3.21 | 10.49 | 1.48 | 82.13 | 59.19 | 21.45 | 19.77 | 14.45 | 2.57 | 14.94 | 0.94 |
| 154 | 2 | 81 | older | Male | Low | 3 | No | NA | DT | HMII | dead | Died | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 155 | 9 | 60 | younger | Female | High | 2 | Yes | Yes | BTT | PVAD | dead | Died | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 156 | 9 | 60 | younger | Female | High | 2 | Yes | Yes | BTT | PVAD | dead | Died | 1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 157 | 9 | 60 | younger | Female | High | 2 | Yes | Yes | BTT | PVAD | dead | Died | 3 | 116462 | 41076 | 35.27 | 95.44 | 33.79 | 25.24 | 84.51 | 15.49 | 2.92 | 0.99 | 45.34 | 13.19 | 39.12 | 2.36 | 17.56 | 8.75 | 19.73 | 79.35 | 5.17 | 10.80 | 0.71 | 90.04 | 29.59 | 10.16 | 6.81 | 8.21 | 3.37 | 4.86 | 4.47 |
| 158 | 9 | 60 | younger | Female | High | 2 | Yes | Yes | BTT | PVAD | dead | Died | 5 | 222650 | 85649 | 38.47 | 98.40 | 32.09 | 19.82 | 77.54 | 22.46 | 5.02 | 1.10 | 43.96 | 19.20 | 33.50 | 3.34 | 17.47 | 9.77 | 15.63 | 71.89 | 6.68 | 14.08 | 0.70 | 86.49 | 27.87 | 13.04 | 9.84 | 12.30 | 4.35 | 7.98 | 6.39 |
| 159 | 9 | 60 | younger | Female | High | 2 | Yes | Yes | BTT | PVAD | dead | Died | 8 | 102274 | 63057 | 61.65 | 97.73 | 27.89 | 20.66 | 73.75 | 26.25 | 7.33 | 3.45 | 35.79 | 21.92 | 37.73 | 4.56 | 9.97 | 8.20 | 16.96 | 63.96 | 2.40 | 11.16 | 3.07 | 73.97 | 5.92 | 16.69 | 17.77 | 11.74 | 4.90 | 12.19 | 6.09 |
| 160 | 9 | 60 | younger | Female | High | 2 | Yes | Yes | BTT | PVAD | dead | Died | 14 | 133530 | 81665 | 61.16 | 96.46 | 22.03 | 16.15 | 35.30 | 64.70 | 13.74 | 2.33 | 8.48 | 52.28 | 26.37 | 12.87 | 5.29 | 5.79 | 19.15 | 47.48 | 5.65 | 17.83 | 5.43 | 39.88 | 6.08 | 52.08 | 62.11 | 37.45 | 21.95 | 50.15 | 3.84 |
| 161 | 9 | 60 | younger | Female | High | 2 | Yes | Yes | BTT | PVAD | dead | Died | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 162 | 1 | 65 | older | Male | High | 2 | No | NA | BTT | HMII | alive | Alive s/p OHT | 0 | 169154 | 35496 | 20.98 | 99.53 | 25.37 | 19.82 | 86.02 | 13.98 | 1.26 | 2.54 | 57.81 | 11.74 | 28.06 | 2.39 | 21.74 | 14.36 | 0.72 | 81.05 | 2.86 | 13.60 | 0.58 | 95.22 | 84.83 | 10.47 | 4.33 | 8.50 | 1.39 | 3.13 | 1.09 |
| 163 | 1 | 65 | older | Male | High | 2 | No | NA | BTT | HMII | alive | Alive s/p OHT | 1 | 63082 | 9915 | 15.72 | 99.26 | 32.45 | 26.26 | 90.06 | 9.94 | 0.89 | 2.09 | 54.27 | 7.70 | 35.71 | 2.32 | 31.10 | 20.47 | 1.57 | 84.06 | 2.59 | 10.79 | 0.26 | 97.02 | 92.59 | 7.50 | 3.13 | 6.42 | 1.32 | 2.44 | 1.49 |
| 164 | 1 | 65 | older | Male | High | 2 | No | NA | BTT | HMII | alive | Alive s/p OHT | 3 | 75921 | 21721 | 28.61 | 99.31 | 24.86 | 33.01 | 86.38 | 13.62 | 1.54 | 1.26 | 45.74 | 10.98 | 40.44 | 2.84 | 31.80 | 18.04 | 1.15 | 86.21 | 4.82 | 6.56 | 0.24 | 90.41 | 73.33 | 10.00 | 7.25 | 10.12 | 3.22 | 5.67 | 2.05 |
| 165 | 1 | 65 | older | Male | High | 2 | No | NA | BTT | HMII | alive | Alive s/p OHT | 5 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 166 | 1 | 65 | older | Male | High | 2 | No | NA | BTT | HMII | alive | Alive s/p OHT | 8 | 213808 | 36002 | 16.84 | 99.19 | 35.95 | 14.55 | 67.94 | 32.06 | 4.06 | 2.17 | 27.92 | 28.92 | 39.64 | 3.52 | 20.31 | 9.10 | 1.33 | 68.69 | 7.10 | 20.42 | 1.88 | 87.38 | 44.25 | 10.78 | 11.12 | 19.15 | 5.54 | 7.35 | 1.07 |
| 167 | 1 | 65 | older | Male | High | 2 | No | NA | BTT | HMII | alive | Alive s/p OHT | 14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 168 | 1 | 65 | older | Male | High | 2 | No | NA | BTT | HMII | alive | Alive s/p OHT | 21 | 106970 | 31867 | 29.79 | 99.18 | 42.36 | 15.02 | 84.69 | 15.31 | 1.94 | 2.11 | 55.41 | 13.14 | 29.13 | 2.32 | 20.22 | 12.88 | 2.08 | 83.21 | 5.20 | 9.50 | 1.10 | 94.44 | 73.00 | 9.04 | 6.99 | 9.22 | 2.80 | 4.78 | 1.44 |
| 169 | 26 | 49 | younger | Male | Low | 3 | No | NA | DT | HMII | alive | Alive | 0 | 196315 | 122053 | 62.17 | 95.37 | 60.66 | 22.66 | 91.10 | 8.90 | 0.45 | 4.95 | 85.57 | 6.30 | 5.42 | 2.71 | 13.13 | 28.32 | 20.05 | 86.32 | 2.45 | 5.42 | 0.96 | 98.68 | 94.19 | 2.50 | 2.96 | 4.63 | 1.24 | 0.33 | 0.89 |
| 170 | 26 | 49 | younger | Male | Low | 3 | No | NA | DT | HMII | alive | Alive | 1 | 91909 | 37622 | 40.93 | 96.10 | 43.22 | 38.85 | 95.48 | 4.52 | 0.14 | 2.19 | 85.07 | 3.09 | 10.33 | 1.51 | 21.03 | 27.23 | 9.08 | 88.84 | 1.13 | 3.91 | 0.23 | 98.77 | 88.27 | 1.16 | 1.16 | 2.34 | 0.38 | 0.21 | 0.45 |
| 171 | 26 | 49 | younger | Male | Low | 3 | No | NA | DT | HMII | alive | Alive | 3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 172 | 26 | 49 | younger | Male | Low | 3 | No | NA | DT | HMII | alive | Alive | 5 | 153762 | 86281 | 56.11 | 95.83 | 65.54 | 24.24 | 91.12 | 8.88 | 0.65 | 2.84 | 81.43 | 6.30 | 9.62 | 2.65 | 21.14 | 28.73 | 15.89 | 83.00 | 1.97 | 6.74 | 0.36 | 98.22 | 93.16 | 3.20 | 2.29 | 5.47 | 1.11 | 0.77 | 1.56 |
| 173 | 26 | 49 | younger | Male | Low | 3 | No | NA | DT | HMII | alive | Alive | 8 | 82406 | 47485 | 57.62 | 92.71 | 65.75 | 17.46 | 91.79 | 8.21 | 1.08 | 1.99 | 76.35 | 5.70 | 15.41 | 2.54 | 20.56 | 26.95 | 11.99 | 78.67 | 1.35 | 7.97 | 0.28 | 97.55 | 85.62 | 2.65 | 2.56 | 5.19 | 1.18 | 0.86 | 1.79 |
| 174 | 26 | 49 | younger | Male | Low | 3 | No | NA | DT | HMII | alive | Alive | 14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 175 | 26 | 49 | younger | Male | Low | 3 | No | NA | DT | HMII | alive | Alive | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 176 | 7 | 49 | younger | Male | Low | 3 | No | No | BTT | HVAD | alive | Alive s/p OHT | 0 | 89251 | 65181 | 73.03 | 76.76 | 84.53 | 1.15 | 74.65 | 25.35 | 1.91 | 1.39 | 55.03 | 22.40 | 19.62 | 2.95 | 15.65 | 6.80 | 25.85 | 70.49 | 0.87 | 23.26 | 0.23 | 83.16 | 25.00 | 8.85 | 5.03 | 11.63 | 1.56 | 2.95 | 3.08 |
| 177 | 7 | 49 | younger | Male | Low | 3 | No | No | BTT | HVAD | alive | Alive s/p OHT | 1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 178 | 7 | 49 | younger | Male | Low | 3 | No | No | BTT | HVAD | alive | Alive s/p OHT | 3 | 375167 | 234817 | 62.59 | 98.46 | 60.29 | 10.18 | 87.72 | 12.28 | 0.46 | 0.48 | 68.54 | 9.90 | 19.03 | 2.54 | 30.58 | 19.69 | 15.54 | 72.77 | 0.13 | 20.35 | 0.03 | 92.56 | 36.28 | 3.75 | 2.70 | 9.17 | 1.19 | 1.27 | 0.63 |
| 179 | 7 | 49 | younger | Male | Low | 3 | No | No | BTT | HVAD | alive | Alive s/p OHT | 5 | 256306 | 162176 | 63.27 | 93.82 | 68.43 | 8.45 | 85.45 | 14.55 | 0.70 | 0.53 | 71.99 | 11.98 | 13.37 | 2.66 | 32.41 | 17.96 | 12.46 | 69.74 | 0.41 | 24.63 | 0.02 | 95.72 | 44.12 | 4.47 | 2.23 | 12.99 | 1.30 | 1.20 | 0.77 |
| 180 | 7 | 49 | younger | Male | Low | 3 | No | No | BTT | HVAD | alive | Alive s/p OHT | 8 | 463136 | 330714 | 71.41 | 98.79 | 70.51 | 7.30 | 87.51 | 12.49 | 1.78 | 0.58 | 69.60 | 10.61 | 17.82 | 1.97 | 29.83 | 14.55 | 12.59 | 75.03 | 0.15 | 21.61 | 0.07 | 93.59 | 30.94 | 4.05 | 3.07 | 10.00 | 1.08 | 1.35 | 0.62 |
| 181 | 7 | 49 | younger | Male | Low | 3 | No | No | BTT | HVAD | alive | Alive s/p OHT | 14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 182 | 7 | 49 | younger | Male | Low | 3 | No | No | BTT | HVAD | alive | Alive s/p OHT | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 183 | 12 | 38 | younger | Male | High | 2 | Yes | Yes | BTT | TAH | dead | Died s/p OHT | 0 | 128451 | 60927 | 47.43 | 96.82 | 60.77 | 4.70 | 77.26 | 22.74 | 2.17 | 1.95 | 55.58 | 18.40 | 21.54 | 4.47 | 27.86 | 18.89 | 15.33 | 69.90 | 0.94 | 24.40 | 0.14 | 70.73 | 1.85 | 8.01 | 8.66 | 20.21 | 5.45 | 3.32 | 0.39 |
| 184 | 12 | 38 | younger | Male | High | 2 | Yes | Yes | BTT | TAH | dead | Died s/p OHT | 1 | 142796 | 22573 | 15.81 | 80.67 | 47.31 | 2.28 | 63.37 | 36.63 | 9.16 | 6.51 | 26.02 | 33.49 | 37.11 | 3.37 | 38.13 | 7.50 | 13.13 | 53.25 | 5.78 | 26.27 | 1.57 | 40.24 | 0.00 | 27.71 | 22.17 | 29.16 | 18.80 | 15.66 | 8.11 |
| 185 | 12 | 38 | younger | Male | High | 2 | Yes | Yes | BTT | TAH | dead | Died s/p OHT | 3 | 157167 | 38008 | 24.18 | 93.47 | 34.86 | 3.95 | 69.71 | 30.29 | 3.92 | 3.92 | 33.64 | 26.30 | 35.78 | 4.28 | 39.54 | 11.49 | 14.94 | 66.86 | 2.85 | 24.31 | 1.04 | 64.50 | 7.27 | 21.60 | 20.53 | 27.66 | 14.54 | 14.18 | 2.12 |
| 186 | 12 | 38 | younger | Male | High | 2 | Yes | Yes | BTT | TAH | dead | Died s/p OHT | 5 | 121823 | 23097 | 18.96 | 93.48 | 2.51 | 2.87 | 99.52 | 0.48 | 0.00 | 0.00 | 0.97 | 0.48 | 98.55 | 0.00 | 50.00 | 25.00 | 25.00 | 94.35 | 0.00 | 2.58 | 0.00 | 0.16 | 0.00 | 17.45 | 87.40 | 0.00 | 0.16 | 18.26 | 0.00 |
| 187 | 12 | 38 | younger | Male | High | 2 | Yes | Yes | BTT | TAH | dead | Died s/p OHT | 8 | 196515 | 88579 | 45.07 | 85.54 | 17.17 | 3.28 | 59.38 | 40.62 | 3.21 | 1.41 | 35.44 | 35.28 | 23.87 | 5.42 | 62.85 | 12.32 | 3.71 | 66.05 | 4.38 | 23.22 | 0.27 | 74.53 | 31.43 | 25.51 | 28.12 | 39.78 | 25.79 | 21.57 | 0.79 |
| 188 | 12 | 38 | younger | Male | High | 2 | Yes | Yes | BTT | TAH | dead | Died s/p OHT | 14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 189 | 12 | 38 | younger | Male | High | 2 | Yes | Yes | BTT | TAH | dead | Died s/p OHT | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 190 | 17 | 68 | older | Male | Low | 3 | No | NA | DT | HMII | dead | Died | 0 | 147997 | 54649 | 36.93 | 91.75 | 79.63 | 7.62 | 74.86 | 25.14 | 0.60 | 3.45 | 62.45 | 22.87 | 12.30 | 2.38 | 45.98 | 9.28 | 13.61 | 74.33 | 2.67 | 21.19 | 0.84 | 91.31 | 90.15 | 3.58 | 2.25 | 21.79 | 1.36 | 0.58 | 0.34 |
| 191 | 17 | 68 | older | Male | Low | 3 | No | NA | DT | HMII | dead | Died | 1 | 177687 | 56400 | 31.74 | 97.13 | 69.76 | 12.60 | 81.83 | 18.17 | 0.65 | 1.61 | 55.77 | 16.13 | 26.02 | 2.09 | 53.19 | 10.70 | 11.57 | 82.92 | 1.38 | 13.98 | 0.28 | 89.83 | 85.59 | 3.78 | 1.85 | 14.65 | 1.30 | 0.68 | 0.18 |
| 192 | 17 | 68 | older | Male | Low | 3 | No | NA | DT | HMII | dead | Died | 3 | 233155 | 67140 | 28.80 | 98.44 | 74.89 | 5.32 | 81.96 | 18.04 | 1.00 | 1.88 | 49.03 | 16.59 | 32.90 | 1.48 | 49.92 | 7.20 | 12.83 | 83.44 | 1.39 | 12.98 | 0.14 | 89.70 | 69.70 | 4.58 | 1.62 | 13.89 | 1.08 | 1.08 | 0.17 |
| 193 | 17 | 68 | older | Male | Low | 3 | No | NA | DT | HMII | dead | Died | 5 | 99257 | 29455 | 29.68 | 97.33 | 62.48 | 4.73 | 80.60 | 19.40 | 1.84 | 1.25 | 45.06 | 18.36 | 35.25 | 1.33 | 44.61 | 6.32 | 12.27 | 82.89 | 0.88 | 13.20 | 0.09 | 83.55 | 35.29 | 7.23 | 3.54 | 14.75 | 2.29 | 3.02 | 1.20 |
| 194 | 17 | 68 | older | Male | Low | 3 | No | NA | DT | HMII | dead | Died | 8 | 76358 | 18702 | 24.49 | 97.32 | 29.48 | 11.10 | 86.29 | 13.71 | 2.43 | 0.50 | 37.92 | 12.13 | 48.32 | 1.63 | 46.45 | 11.70 | 11.35 | 83.96 | 0.20 | 10.50 | 0.06 | 57.82 | 50.00 | 9.95 | 29.60 | 10.20 | 0.64 | 9.36 | 0.80 |
| 195 | 17 | 68 | older | Male | Low | 3 | No | NA | DT | HMII | dead | Died | 14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 196 | 17 | 68 | older | Male | Low | 3 | No | NA | DT | HMII | dead | Died | 21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
df.temp <- df
colnames(df.temp) <- make.names(colnames(df), unique = T)
invisible(suppressWarnings(suppressMessages(ggpairs(df.temp,
mapping = aes(color = Survival),
columns = colnames(df.temp)[c(2,4,6,7,8,9,10,11)])
)))
require(pheatmap, quietly = T)
require(RColorBrewer, quietly = T)
r <- cor(df[,c(2,14:42)], use = "p")
pheatmap(r,
color = colorRampPalette(rev(brewer.pal(n = 7, name = "RdBu")))(100),
breaks = seq(-1, 1, length.out = 100),
fontsize = 6,
cutree_rows = 5,
cutree_cols = 5
)
We identified large variability between individual patients, as well as device types.
suppressMessages(require(ggbiplot, quietly = T))
require(ggsci, quietly = T)
# Efron's double standardization
double_standardize <- function(x, niter = 100) {
for(i in 1:niter) x <- t(scale(t(scale(x))))
return(as.data.frame(x))
}
isna <- unique(unlist(apply(df[,14:42], 2, function(x) which(is.na(x)))))
pca <- prcomp(double_standardize(df[-isna, 14:42]), center = TRUE, scale. = TRUE)
colorfun <- function(grouping, ...){
if(nlevels(factor(grouping)) > 10) scale_color_discrete(...)
if(nlevels(factor(grouping)) <=10) scale_color_d3(...)
}
plots.pca <- lapply(names(df)[1:17], function(this_var){
this_groups <- df[-isna, this_var]
if(is.numeric(this_groups)) this_groups <- cut(this_groups, 4)
ggbiplot(pca,
groups = this_groups,
ellipse = TRUE,
alpha = 0.3,
varname.size = 1.2) +
colorfun(this_groups, name = this_var) +
ggtitle(paste0(this_var, " variability")) +
theme_classic()
})
names(plots.pca) <- names(df)[1:17]
plots.pca$PatientID
plots.pca$`Device Type`
# for(ii in 1:length(plots.pca)) suppressWarnings(print(plots.pca[[ii]]))
We analyzed the differences between device types using Fisher’s exact test. The following tables are statistically significant (q<0.05).
isfactor <- which(sapply(df, is.factor))[-1]
contingency <- lapply(isfactor, function(this_factor) table(df[,this_factor], df$`Device Type`))
fisher.p <- sapply(contingency, function(this_table){
f <- fisher.test(this_table, simulate.p.value = T, B = 10000)
f$p.value
})
contingency[which(p.adjust(fisher.p, method = "BH") < 0.05)]
## $AgeGreater60
##
## CMAG HMII HVAD PVAD TAH
## younger 0 56 7 21 7
## older 7 84 7 0 7
##
## $Sex
##
## CMAG HMII HVAD PVAD TAH
## Female 0 35 0 14 0
## Male 7 105 14 7 14
##
## $LowIntermacs
##
## CMAG HMII HVAD PVAD TAH
## Low 0 63 14 0 0
## High 7 77 0 21 14
##
## $InterMACS
##
## CMAG HMII HVAD PVAD TAH
## 1 0 7 0 0 7
## 2 7 70 0 21 7
## 3 0 56 14 0 0
## 4 0 7 0 0 0
##
## $RVAD
##
## CMAG HMII HVAD PVAD TAH
## No 7 105 14 0 0
## Yes 0 35 0 21 14
##
## $Sensitized
##
## CMAG HMII HVAD PVAD TAH
## No 0 42 7 0 7
## Yes 0 28 7 7 7
##
## $`VAD Indication`
##
## CMAG HMII HVAD PVAD TAH
## BTT 7 98 14 21 14
## DT 0 42 0 0 0
##
## $`Device Type`
##
## CMAG HMII HVAD PVAD TAH
## CMAG 7 0 0 0 0
## HMII 0 140 0 0 0
## HVAD 0 0 14 0 0
## PVAD 0 0 0 21 0
## TAH 0 0 0 0 14
##
## $Survival
##
## CMAG HMII HVAD PVAD TAH
## alive 0 98 14 7 7
## dead 7 42 0 14 7
##
## $Outcome
##
## CMAG HMII HVAD PVAD TAH
## Alive 0 28 0 0 0
## Alive s/p OHT 0 70 14 7 7
## Died 7 35 0 7 0
## Died post OHT 0 7 0 0 0
## Died s/p OHT 0 0 0 7 7
We analyzed the differences between device types using a mixed effect model.
suppressMessages(require(lmerTest, quietly = T))
suppressMessages(require(car, quietly = TRUE))
df.device <- df
colnames(df.device) <- make.names(colnames(df), unique = T)
varnames <- colnames(df.device)[14:42]
models.device <- lapply(varnames, function(this_var){
this_formula <- as.formula(paste0(this_var, " ~ Device.Type * factor(Time) + (1|PatientID)"))
invisible(suppressMessages(this_model <- lmer(this_formula, data = df.device)))
this_anova <- Anova(this_model, type = 2)
pvals <- this_anova$`Pr(>Chisq)`[c(1,3)]
return(list(model = this_model,
pvals = pvals))
})
names(models.device) <- colnames(df)[14:42]
pvals <- do.call(rbind, lapply(models.device, function(x) x$pvals))
rownames(pvals) <- varnames
colnames(pvals) <- c("Device", "Device:factor(Time)")
qBH <- matrix(p.adjust(pvals, method = "BH"), nrow = nrow(pvals))
rownames(qBH) <- colnames(df)[14:42]
colnames(qBH) <- colnames(pvals)
sigvars <- apply(apply(qBH, 2, function(x) x<=0.1), 1, function(x) sum(x) > 0)
sig.qtable <- qBH[sigvars,][order(qBH[sigvars,2]),]
kable(sig.qtable,
digits = 10,
row.names = T,
caption = "Significant device-type q-values") %>%
kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive"),
font_size = 10) %>%
scroll_box(width = "100%", height = "300px")
| Device | Device:factor(Time) | |
|---|---|---|
| CD19+CD5+ | 0.18837680 | 0.0000000002 |
| CD27+IgD- switched memory | 0.35405042 | 0.0000058050 |
| CD19+CD27+ | 0.57707197 | 0.0000518816 |
| CD27-IgD- switched memory | 0.57707197 | 0.0000518816 |
| CD19+CD11b+ | 0.65950106 | 0.0013452317 |
| CD27-IgD+ mature naive | 0.07734532 | 0.0026478333 |
| CD19CD24hiCD38-memory | 0.97000494 | 0.0100899431 |
| CD19+24dim38dim naive mature | 0.99997840 | 0.0570900512 |
| CD19+CD27+CD24hi | 0.97000494 | 0.0666230567 |
require(reshape2, quietly = T)
df.long <- melt(df, id.vars = colnames(df)[1:13])
groups <- make.names(c("Device Type"))
names(df.long) <- make.names(names(df.long))
invisible(suppressMessages(require(Hmisc, quietly = T)))
stat_sum_df <- function(fun, geom="errorbar", ...) {
stat_summary(fun.data = fun, geom = geom, width = 1, ...)
}
plots.ts <- lapply(rownames(sig.qtable), function(this_var){
lapply(groups, function(this_groups){
ggplot(subset(df.long, df.long$variable == this_var)) +
aes(x = Time, y = value, group = PatientID) +
aes_string(color = this_groups, fill = this_groups) +
geom_line(alpha = 0) +
geom_point(alpha = 0) +
stat_summary(fun.y = mean, aes_string(group = this_groups), geom=c("point"), position = position_dodge(.5)) +
stat_summary(fun.y = mean, aes_string(group = this_groups), geom=c("line"), position = position_dodge(.5)) +
stat_sum_df(function(x) mean_cl_boot(x, conf.int = 0.68), mapping = aes_string(group = this_groups), position = position_dodge(.5)) +
#stat_smooth(aes_string(group = this_groups), method = "loess", span = 1) +
scale_color_d3() + scale_fill_d3() +
xlab("Time (days after surgery)") +
ylab(this_var) +
ggtitle(paste(this_var)) +
theme_classic()
})
})
names(plots.ts) <- rownames(sig.qtable)
for(ii in c(1:length(plots.ts))){
for(jj in 1:length(plots.ts[[ii]])){
sumtable <- suppressMessages(summary(models.device[[rownames(sig.qtable)[ii]]]$model))
sumtable <- sumtable$coefficients[-1, c(4:5)] # drop intercept
sigsum <- sumtable[sumtable[,2] <= 0.05, , drop = F]
print(sigsum)
suppressWarnings(print(plots.ts[[ii]][[jj]]))
}
}
## t value Pr(>|t|)
## Device.TypePVAD:factor(Time)3 -3.212790 1.985064e-03
## Device.TypeTAH:factor(Time)5 5.597892 4.249332e-07
## t value Pr(>|t|)
## Device.TypeHVAD:factor(Time)1 2.193867 3.164541e-02
## Device.TypePVAD:factor(Time)3 -4.506401 2.595755e-05
## t value Pr(>|t|)
## Device.TypeHVAD:factor(Time)1 2.288402 2.520393e-02
## Device.TypePVAD:factor(Time)3 -4.140293 9.549563e-05
## t value Pr(>|t|)
## factor(Time)14 2.658002 9.549567e-03
## Device.TypeTAH:factor(Time)5 4.417748 3.766149e-05
## Device.TypeHMII:factor(Time)14 -2.262837 2.647667e-02
## Device.TypeHVAD:factor(Time)14 -2.248730 2.747890e-02
## Device.TypePVAD:factor(Time)14 -2.015937 4.729750e-02
## t value Pr(>|t|)
## factor(Time)14 5.663951 2.822395e-07
## factor(Time)21 2.286686 2.529833e-02
## Device.TypeHMII:factor(Time)3 -2.083219 4.087800e-02
## Device.TypePVAD:factor(Time)3 -2.149256 3.501689e-02
## Device.TypeHMII:factor(Time)14 -5.250946 1.469192e-06
## Device.TypeHVAD:factor(Time)14 -4.341077 4.591232e-05
## Device.TypePVAD:factor(Time)14 -2.999221 3.710150e-03
## t value Pr(>|t|)
## factor(Time)14 -3.556174 6.728955e-04
## Device.TypeTAH:factor(Time)1 -2.304827 2.419980e-02
## Device.TypeTAH:factor(Time)5 -4.252348 6.589494e-05
## Device.TypeTAH:factor(Time)8 -2.129620 3.678382e-02
## Device.TypeHMII:factor(Time)14 2.953963 4.249260e-03
## Device.TypeHVAD:factor(Time)14 2.846370 5.784388e-03
## Device.TypePVAD:factor(Time)14 2.624952 1.059141e-02
## t value Pr(>|t|)
## Device.TypeHVAD:factor(Time)1 2.07174 0.04206401
## t value Pr(>|t|)
## Device.TypePVAD:factor(Time)3 -2.848022 0.005697037
## t value Pr(>|t|)
## Device.TypeHVAD:factor(Time)1 2.218908 0.02978656
require(reshape2, quietly = T)
df.HMII <- subset(df, df$`Device Type`=="HMII")
df.long <- melt(df.HMII, id.vars = colnames(df)[1:13])
groups <- make.names(c("AgeGreater60",
"Sex",
"LowIntermacs",
"RVAD",
"Sensitized",
"VAD Indication",
#"Device Type",
"Survival",
"Outcome"))
names(df.long) <- make.names(names(df.long))
plots.ts <- lapply(unique(df.long$variable), function(this_var){
lapply(groups, function(this_groups){
ggplot(subset(df.long, df.long$variable == this_var)) +
aes(x = Time, y = value, group = PatientID) +
aes_string(color = this_groups, fill = this_groups) +
geom_line(alpha = 0) +
geom_point(alpha = 0) +
#stat_smooth(aes_string(group = this_groups), method = "loess", span = 1) +
stat_summary(fun.y = mean, aes_string(group = this_groups), geom=c("point"), position = position_dodge(.5)) +
stat_summary(fun.y = mean, aes_string(group = this_groups), geom=c("line"), position = position_dodge(.5)) +
stat_sum_df(function(x) mean_cl_boot(x, conf.int = 0.68), mapping = aes_string(group = this_groups), position = position_dodge(.5)) +
scale_color_aaas() + scale_fill_aaas() +
xlab("Time (days after surgery)") +
ylab(this_var) +
ggtitle(paste(this_var)) +
theme_classic()
})
})
names(plots.ts) <- unique(df.long$variable)
# for(ii in c(1:length(plots.ts))){
# for(jj in 1:length(plots.ts[[ii]])){
# suppressWarnings(print(plots.ts[[ii]][[jj]]))
# }
# }
suppressMessages(require(lmerTest, quietly = TRUE))
suppressMessages(require(car, quietly = TRUE))
require(reshape2, quietly = TRUE)
df.lmer <- df.HMII
names(df.lmer) <- make.names(names(df.lmer), unique = TRUE)
groupvars.ix <- c(3,4,5,7,8,9,11)
groupvars <- names(df.lmer)[groupvars.ix]
bcells.ix <- c(14:42)
bcells <- names(df.lmer)[bcells.ix]
pvals <- lapply(groupvars, function(this_groupvar){
these_pvalues <- lapply(bcells, function(this_bcell){
this_formula <- as.formula(paste0(this_bcell, " ~ ", this_groupvar,
" * factor(Time) + (1|PatientID)"))
suppressMessages(suppressWarnings(this_model <- lmer(this_formula, data = droplevels(df.lmer))))
this_anova <- Anova(this_model, type = 2)
this_pvalues <- this_anova$`Pr(>Chisq)`
names(this_pvalues) <- rownames(this_anova)
return(this_pvalues)
})
pvalues <- do.call(rbind, these_pvalues)
rownames(pvalues) <- bcells
return(pvalues)
})
names(pvals) <- groupvars
pvals.matrix <- do.call(cbind, lapply(pvals, function(this_pval) this_pval[,c(1,3)]))
# Benjamini Hochberg
# qBH <- matrix(p.adjust(as.numeric(pvals.matrix),
# method = "BH"),
# nrow = nrow(pvals.matrix),
# ncol = ncol(pvals.matrix),
# byrow = F)
# rownames(qBH) <- rownames(pvals.matrix)
# colnames(qBH) <- colnames(pvals.matrix)
# rownames(qBH) <- names(df)[bcells.ix]
# qvalsBH.df <- melt(qBH)
# colnames(qvalsBH.df) <- c("B-cell", "parameter", "qvalue")
# qvalsBH.df.ranked <- qvalsBH.df[order(qvalsBH.df$qvalue, decreasing = F),]
# qvalsBH.df.ranked[qvalsBH.df.ranked$qvalue <= 0.3,]
# Local FDR
require(fdrtool, quietly = T)
invisible(suppressMessages(fdrobj <- fdrtool(as.numeric(pvals.matrix), statistic = "pvalue", plot = F)))
## Step 1... determine cutoff point
## Step 2... estimate parameters of null distribution and eta0
## Step 3... compute p-values and estimate empirical PDF/CDF
## Step 4... compute q-values and local fdr
qvals.matrix <- matrix(fdrobj$q, nrow = nrow(pvals.matrix), ncol = ncol(pvals.matrix), byrow = F)
rownames(qvals.matrix) <- rownames(pvals.matrix)
colnames(qvals.matrix) <- colnames(pvals.matrix)
rownames(qvals.matrix) <- names(df)[bcells.ix]
qvals.df <- melt(qvals.matrix)
colnames(qvals.df) <- c("B-cell", "parameter", "qvalue")
qvals.df.ranked <- qvals.df[order(qvals.df$qvalue, decreasing = F),]
shortlist <- qvals.df.ranked[qvals.df.ranked$qvalue <= 0.3,]
kable(shortlist,
digits = 3,
row.names = T,
caption = "Significant results") %>%
kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive"),
font_size = 10) %>%
scroll_box(width = "100%", height = "300px")
| B-cell | parameter | qvalue | |
|---|---|---|---|
| 2 | num lymph | AgeGreater60 | 0.040 |
| 145 | CD19+27+IgD-38++IgG ASC | LowIntermacs | 0.040 |
| 52 | CD268 of +27-38++transitional | AgeGreater60:factor(Time) | 0.073 |
| 276 | CD27+IgD-IgM+ switched memory | Sensitized:factor(Time) | 0.081 |
| 61 | lymph | Sex | 0.200 |
| 348 | CD19+27+IgD-38++IgG ASC | VAD.Indication:factor(Time) | 0.213 |
| 232 | CD19+27+IgD-38++IgG ASC | RVAD:factor(Time) | 0.230 |
| 155 | CD27-38++ transitional | LowIntermacs:factor(Time) | 0.254 |
| 3 | lymph | AgeGreater60 | 0.257 |
require(stringr, quietly = T)
siggroups <- sapply(str_split(shortlist$parameter, ":"), function(x) x[1])
for(ii in 1:nrow(shortlist)){
this_group <-siggroups[ii]
suppressWarnings(print(plots.ts[[shortlist$`B-cell`[ii]]][[which(groups == this_group)]]))
}